Metabolism of free fatty acids in patients with gastrointestinal diseases depending on the body mass index

Background. The purpose of the study is to analyze content free fatty acids (FFA) in blood serum overweight and underweight patients with gastrointestinal diseases. Mate­rials methods. Thirty-one diseases were examined, 19 (61.3 %) men 12 (38.7 women a median age 39 (27; 48) years. Depending on results body composition multifunctional monitor TANITA MC-780MA (Japan), they divided into following groups: (body mass index (BMI) more than 25.0 kg/m2) persons (BMI below 18.5 kg/m2). Determination FFA spectrum was carried out using gas chromatograph flame ionization detector Chromatek-Crystal 5000. control group consisted 16 practically healthy people. Statistical processing Statistica 6.1 application program package. Results. Patients change weight reported statistically significant decrease total short-chain saturated (C4:0) mainly due butyric acid by 67 times (p = 0.001) increased BMI 114 0.002) decreased compared controls. At same time, analysis an average carbon chain length showed probable increase capric 14 < 0.01), undecyl lauric 25 changes weight. caproic excessive 3.9 0.046) controls 2.6 > 0.05) patients. monounsaturated significantly 32 0.001), respectively, polyunsaturated both groups found trace amount. Overweight had 38-fold 0.01) trans-FFA elaidic (C18:1(trans-9)) controls, while linoelaidic (C18:2(trans-9,12)) 11.7 0.05). Correlation revealed positive relationship between (r 0.39; p 0.019); — palmitoleic 0.33; р 0.045) heptadecenoic 0.35; 0.034); trans-configuration 0.43; 0.009) 0.007). Conclusions. imbalance serum. Against background tendency FFA, noted, especially BMI. In all patients, amount fractions found. obtained can be used improve differential treatment metabolic disorders tract pathology.